TIP UPJŠ — Technologický a inovačný park metabolitemarket.com

Portfolio A — Secondary Metabolites

Lichen compounds with published bioactivity.

Isolated, NMR-confirmed depsides, depsidones and dibenzofurans from Slovak lichen populations. Antioxidant, antiproliferative and antimicrobial data come from peer-reviewed studies by the Goga and Kello groups, and every source article is linked under Evidence. All findings in this line are in vitro; materials are supplied for research use, and nothing here is a clinical, therapeutic or regulatory claim.

Work in this line is led by doc. RNDr. Michal Goga, PhD. and RNDr. Martin Kello, PhD..

A1Lead compound

Depside · Umbilicaria hirsuta

Gyrophoric Acid Platform

The best-characterised compound in the portfolio. Published work reports ROS production, apoptosis and modulation of Akt, Erk1/2 and p38 MAPK in HeLa cells, with a validated isolation protocol giving high-purity material.

  • Antiproliferative screening
  • ROS / oxidative stress
  • Apoptosis
  • HeLa model
Evidence
Peer-reviewed 2019 · mechanistic dataset
Stage
Pilot-ready · licensing open
Indicative
€ 8 000 – 35 000negotiable by scope and application
A2

Depsidone · Hypogymnia physodes

3-Hydroxyphysodic Acid Antioxidant Line

The strongest radical scavenger in our comparative metabolite study — and the comparison was made per mole rather than per unit weight. That distinction matters when you translate a screening result into a formulation dose.

  • Antioxidant discovery
  • Cosmetic actives
  • Nutraceuticals
Evidence
Peer-reviewed 2022 · DPPH + superoxide
Stage
Pilot-ready · licensing open
Indicative
€ 5 000 – 25 000negotiable by scope and application
A3

Depside · Reference metabolite

Atranorin Bioactivity Line

A widely cited lichen compound with repeatedly published bioactivity, included in both of our screening studies. A dependable reference compound and panel anchor for antiproliferative, antioxidant and antimicrobial work.

  • Cytotoxicity
  • Redox modulation
  • Reference standard
Evidence
Peer-reviewed 2022 & 2023
Stage
Pilot-ready · licensing open
Indicative
€ 4 000 – 22 000negotiable by scope and application
A4

Depsidone · Hypogymnia physodes

Physodic Acid Bioactivity Line

Present in both of our published panels, with antioxidant and antiproliferative activity reported in 2D and 3D models. A natural comparator when you want to benchmark a candidate against gyrophoric acid within one experimental system.

  • Antioxidant
  • Antiproliferative
  • Panel candidate
Evidence
Peer-reviewed 2022 & 2023
Stage
Pilot-ready · licensing open
Indicative
€ 5 000 – 25 000negotiable by scope and application
A5

Depside · Evernia prunastri

Evernic Acid Natural Antioxidant Line

Isolated from Evernia prunastri and tested in DPPH and superoxide anion scavenging assays in our 2022 comparative study, then carried into the 2023 multi-compound panel. Clear positioning for cosmetic and nutraceutical antioxidant discovery.

  • Natural antioxidant
  • Cosmetics
  • Nutraceuticals
Evidence
Peer-reviewed 2022 & 2023
Stage
Pilot-ready · licensing open
Indicative
€ 4 000 – 20 000negotiable by scope and application
A6Research use only

Dibenzofuran · Benchmark compound

Usnic Acid Benchmark Line

The standard reference metabolite for benchmarking cytotoxicity and antioxidant assays, and a control compound in multi-metabolite panels. Supplied for research use only — significant toxicological caution is required before any consumer positioning.

  • Benchmark assay
  • Research use
  • Toxicological caution
Evidence
Peer-reviewed 2022 (comparative)
Stage
Pilot-ready · RUO material
Indicative
€ 3 000 – 18 000negotiable by scope and application
A7Fastest entry point

Standardised crude / semi-purified extracts · 5–10 species

Lichen Extract Bioactivity Panels

The quickest way to see what lichen chemistry can do for your pipeline. Panels of Pseudevernia furfuracea, Lobaria pulmonaria, Cetraria islandica, Umbilicaria hirsuta and related species, with HPLC/LC-MS profiling plus antioxidant, antimicrobial and cell viability assays. You receive a shortlist of active candidates with data.

  • Discovery screening
  • Multi-species panel
  • Antiproliferative
  • Antimicrobial
  • Antioxidant
  • Lead fractionation
Evidence
Peer-reviewed 2023 · profiling data
Stage
Pilot-ready · 8–12 weeks
Indicative
€ 8 000 – 40 000lead isolation quoted individually

Tell us what you are trying to achieve.

A free 30-minute call establishes whether there is a fit and what the right next step is. Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.