A4 Secondary Metabolites · Depsidone · Hypogymnia physodes

Physodic Acid Bioactivity Line

Present in both of our published panels, with antioxidant and antiproliferative activity reported in 2D and 3D models. A natural comparator when you want to benchmark a candidate against gyrophoric acid within one experimental system.

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Evidence: Peer-reviewed 2022 & 2023
Stage: Pilot-ready · licensing open
Indicative: € 5 000 – 25 000negotiable by scope and application

Scientific summary

Physodic acid appears in both of our published datasets. In the 2022 comparative study it was tested for DPPH and superoxide anion scavenging on a molar basis; in the 2023 screening panel it was one of four isolated metabolites assessed for antiproliferative activity in 2D and 3D cancer models, together with antimicrobial testing.

Where it fits

Physodic acid is the natural comparator when a programme is built around gyrophoric acid or atranorin: same chemical family, different substitution pattern, measured in the same systems. That makes structure–activity reasoning possible without importing results from other laboratories.

Applications

Antioxidant screening
Antiproliferative screening
Cell-stress pathway candidate
Structure–activity comparison

Assays & readouts available

DPPH and superoxide scavenging
2D and 3D viability
In vitro antimicrobial testing
NMR structural confirmation

Specification

Compound class	Depsidone (lichen secondary metabolite)
Biological source	Hypogymnia physodes
Evidence status	Published evidence (in vitro), two independent studies
Publications	Elečko J et al., Plants 2022;11(8):1077 · Kello M et al., Plants 2023;12(3):611
Typical pilot	Bioactivity pilot 4–8 weeks
Deliverables	Isolated material, comparative data, technical report
Engagement	Feasibility scan · pilot · licensing
Indicative price	€ 5 000 – 25 000, negotiable by scope and application

What happens next

Book a call or send an inquiry. Tell us the target, the application and the timeline.
We answer within three working days — including when the answer is that we cannot help.
NDA before disclosure, if you need one. Tick the box on the form.
Feasibility scan or pilot proposal with a defined scope, deliverable and price.

Book a 30-minute discovery call Send an inquiry

Common questions

How does an engagement start?

With a free 30-minute discovery call. We establish whether there is a fit and what the right next step is. Nothing is committed at that point.

Can we sign an NDA before we describe our project?

Yes. Tick the NDA box on the inquiry form and we arrange it before any disclosure.

Are the prices on this site binding?

No. They are indicative ranges so that you can size a project before contacting us. Final terms are negotiated per scope.

How quickly do you reply?

Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

What happens if you cannot help?

We say so, early, and where we can we point you to someone who can. A negative feasibility answer delivered quickly is a useful result.

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Evidence: Peer-reviewed 2022 & 2023
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Indicative: € 4 000 – 22 000negotiable by scope and application

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Tell us what you are trying to achieve.

A free 30-minute call establishes whether there is a fit and what the right next step is. Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

Book a 30-minute discovery call Send an inquiry instead