B2 Proteins & Enzymes · Enzyme engineering · Directed evolution

Haloalkane Dehalogenase Engineering Platform

Carbon–halogen bond cleavage for remediation and industrial process chemistry. Directed evolution, ribosome display and catalytic optimisation applied to your substrate — relevant wherever a process generates or handles halogenated streams.

Book a 30-minute discovery call Request the data package

Evidence: Capability & method data under NDA
Stage: Pilot-ready · licensing open
Indicative: € 15 000 – 120 000negotiable by scope and application

What the platform does

Haloalkane dehalogenases cleave carbon–halogen bonds. Wild-type enzymes rarely have the activity, stability or substrate range an industrial process needs, so the platform applies directed evolution and display-based selection to move the enzyme towards your substrate and your conditions.

Who this is for

Processes that generate or handle halogenated streams, remediation programmes with a defined contaminant, and green-chemistry substitutions where a biocatalytic step could replace a harsher chemical one. The first question is always whether your specific substrate is tractable — which is a feasibility scan, not a full campaign.

Applications

Biocatalysis on halogenated substrates
Bioremediation of contaminated streams
Green chemistry process substitution
Enzyme variant libraries for a target reaction

Methods available

Directed evolution campaigns
Ribosome display selection
Catalytic efficiency optimisation
Stability and condition profiling

Specification

Technology type	Enzyme engineering / directed evolution
Research group	CIB — Centre for Interdisciplinary Biosciences
Evidence status	Pilot-ready capability; method and validation data under NDA
Typical pilot	Feasibility scan first, then a multi-month programme
Deliverables	Engineered variants, activity and stability data, method report
Engagement	Feasibility scan · programme · licensing · co-development
Indicative price	€ 15 000 – 120 000, negotiable by scope and application

What happens next

Book a call or send an inquiry. Tell us the target, the application and the timeline.
We answer within three working days — including when the answer is that we cannot help.
NDA before disclosure, if you need one. Tick the box on the form.
Feasibility scan or pilot proposal with a defined scope, deliverable and price.

Book a 30-minute discovery call Send an inquiry

Common questions

How does an engagement start?

With a free 30-minute discovery call. We establish whether there is a fit and what the right next step is. Nothing is committed at that point.

Can we sign an NDA before we describe our project?

Yes. Tick the NDA box on the inquiry form and we arrange it before any disclosure.

Are the prices on this site binding?

No. They are indicative ranges so that you can size a project before contacting us. Final terms are negotiated per scope.

How quickly do you reply?

Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

What happens if you cannot help?

We say so, early, and where we can we point you to someone who can. A negative feasibility answer delivered quickly is a useful result.

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Tell us what you are trying to achieve.

A free 30-minute call establishes whether there is a fit and what the right next step is. Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

Book a 30-minute discovery call Send an inquiry instead